amnesia_scan

Ribbon

pdb93_2ibp-rasmol

There are 2 types of day traders: institutional and retail. Both institutional and retail day traders are described as speculators, as opposed to investors.
Institutional day traders work for financial institutions and have certain advantages over retail traders due to their access to more resources, tools, equipment, large amounts of capital and leverage, large availability of fresh fund inflows to trade continuously on the markets

black_metal_logo_2_by_zumppa-d4sitno

In the past, most day traders were institutional traders due to the advantages they had over retail traders. However, since the technology boom in the second half of the 1990s, advances in personal computing and communications technology, realized in the accessibility of powerful personal computers and the Internet, have brought fast online trading and powerful market analytical tools to the mainstream. Low, affordable commissions from discount brokers as well as regulation improvements in favor of retail traders have also helped level the trading playing field, making success as a retail trader a possibility for many and a reality for some.

enzyme

There are 2 types of day traders: institutional and retail. Both institutional and retail day traders are described as speculators, as opposed to investors.
Institutional day traders work for financial institutions and have certain advantages over retail traders due to their access to more resources, tools, equipment, large amounts of capital and leverage, large availability of fresh fund inflows to trade continuously on the markets, dedicated and direct lines to data centers and exchanges, expensive and high-end trading and analytical software, support teams to help and more. These advantages give them certain edges over retail day traders.[1]
Retail day traders work for themselves, or in partnership with a few other traders. Retail traders generally trade with their own capital, though they may also trade with other people’s money. Laws may restrict the amount of other people’s money a retail trader can manage. In the United States, day traders may not advertise as advisors or financial managers. Although not required, nearly all retail day traders use direct access brokers as they offer the fastest order entry to the exchanges, as well as superior software trading platforms.

Auto traders auto-trade, which stands for automated trading and the use of computer programs and other tools to enter trading orders. Because this all happens with the help of the computer algorithm it is also called algorithmic trading.[2]

1

Injectable Audible Beeping Tags
10:51 am January 31, 2015

I have no idea what the potential applications or extensions might be for this, but it’s a thing I just found so I figured I’d share.

http://www.gizmag.com/injectable-acoustic-fish-tag/35858/

New protein detonates ‘invincible’ bacteria from within
12:00 am January 29, 2015

New protein detonates ‘invincible’ bacteria from within <br>Antibiotic-resistant infections are on the rise, foiling efforts to reduce death rates in developing countries where uncontrolled use of antibiotics and poor sanitation run amok. The epidemic of bacteria resistant to antibiotics knows no borders, present

2M8H
10:41 am January 28, 2015

RRM domain of human RBM7

2MJ4
10:41 am January 28, 2015

Neurotoxin II from snake venom Naja Oxiana in solution

Any Gains Being Made In NFC Storage Size?
2:04 am January 28, 2015

I have an NFC chip implanted right now which I love. When people ask what it does I usually end up saying that it is like a little mini usb drive. So, naturally, I started to dream of the day when the implants will have GBs of storage space. It got me thinking that I haven’t heard anything on here about anyone trying to increase storage capacity on NFC chips. Im sure that it is really hard to do, and I would really just be happy with enough storage to save a word document to (like 125 kbs). So I guess my question is, is anyone working on increasing storage capacity? Or would it make the implants too big?

This week’s new structures (Tuesday Jan 27, 2015 at 4 PM PST)
12:09 am January 28, 2015

As of Tuesday Jan 27, 2015 at 4 PM PST there are 106082 Structures.
New Structure ID List:
[2M8H, 2MJ4, 2MJO, 2MJY, 2MM8, 2MMM, 2MR7, 2MR8, 2MS5, 2MS6, 2MUY, 2MV3, 2MW3, 2MXV, 3J94, 3J95, 3J96, 3J97, 3J98, 3J99, 3WNW, 3WQC, 3WQD, 3WQE, 3WQF, 3WQG, 3WVM, 3X15, 4CEG, 4CI6, 4CJZ, 4CK0, 4CKV, 4CL2, 4CL7, 4CRJ, 4CWB, 4CYU, 4D7Y, 4M8S, 4O9U, 4OHQ, 4OJA, 4OJF, 4OL4, 4OL7, 4OM8, 4OMM, 4OMQ, 4OPB, 4OTF, 4OUD, 4PVF, 4PYX, 4PYY, 4PZH, 4Q06, 4Q07, 4Q08, 4Q09, 4Q0L, 4QFK, 4QFL, 4QFN, 4QFO, 4QFP, 4QGV, 4QGW, 4QGX, 4QY0, 4QY1, 4QY2, 4R0V, 4R3O, 4R4X, 4R4Z, 4RE5, 4RE6, 4RES, 4RET, 4RFV, 4RIE, 4RIF, 4RIG, 4RIH, 4RII, 4RL1, 4RN4, 4RPI, 4RQL, 4RRT, 4RTB, 4RUI, 4RV7, 4RVD, 4RVF, 4RVG, 4RVH, 4RW0, 4RXJ, 4RY3, 4RYE, 4RYI, 4RYM, 4RYQ, 4RYR, 4S17, 4S1A, 4S1H, 4S1M, 4S1N, 4S1P, 4S1V, 4TJZ, 4TKB, 4TKH, 4TKJ, 4TTT, 4TUZ, 4TV1, 4TZ6, 4U9V, 4U9W, 4UA3, 4UP4, 4UT6, 4UT7, 4UT9, 4UTA, 4UTB, 4UTC, 4V0Q, 4V0R, 4WBK, 4WD1, 4WOS, 4WOY, 4WPO, 4WQ4, 4WQ5, 4WQF, 4WQU, 4WQY, 4WV4, 4WV6, 4WXI, 4WZ2, 4WZN, 4X0E, 4X2Z, 4X6B, 4X6C, 4X6D, 4X6E, 4X7J, 4X7K, 4X7L, 4X7N, 4X7O, 4X8B, 4X8C, 4X8D, 4X8E, 4X8G, 4X8N, 4X8P, 4XA9, 4XEQ, 4XF5, 4XFE, 4XFR, 4XHD, 4XKK, 4XLO, 4XLT, 4XOX, 4XP7, 4XR7]

Respiratory chain: protein complex structure revealed
12:00 am January 28, 2015

Respiratory chain: protein complex structure revealed <br>Biochemists have unlocked the structure of mitochondrial complex 1, a large protein complex in the respiratory chain, and at the same time learned new aspects of its function.

How to unboil an egg
12:00 am January 27, 2015

How to unboil an egg<br>UC Irvine and Australian chemists have found out how to unboil egg whites – an innovation that could dramatically reduce costs for cancer treatments, food production and other parts of the biotechnology industry.

Telomere extension turns back aging clock in cultured human cells
12:00 am January 26, 2015

Telomere extension turns back aging clock in cultured human cells<br>A new procedure can quickly and efficiently increase the length of human telomeres, the protective caps on the ends of chromosomes that are linked to aging and disease, according to scientists at the Stanford University School of Medicine.

Next Infrastructure Skype Call
7:17 pm January 25, 2015

Hey guys next infrastructure skype meeting is being planned. Please go fill out the doodle poll if you plan on attending. We may need to break up into group or teams to focus on specific problems simply due to all the chaos and lag that comes from large skype calls.


Hope to hear from you guys :) 
Genome-wide search reveals new genes involved in long-term memory
12:00 am January 23, 2015

Genome-wide search reveals new genes involved in long-term memory <br>A new study has identified genes involved in long-term memory in the worm as part of research aimed at finding ways to retain cognitive abilities during aging.

Subunit disassembly and inhibition of TNF{alpha} by a semi-synthetic bicyclic peptide
3:56 pm January 22, 2015

Macrocyclic peptides are potentially a source of powerful drugs, but their de novo discovery remains challenging. Here we describe the discovery of a high-affinity (Kd = 10 nM) peptide macrocycle (M21) against human tumor necrosis factor-alpha (hTNFα), a key drug target in the treatment of inflammatory disorders, directly from diverse semi-synthetic phage peptide repertoires. The bicyclic peptide M21 (ACPPCLWQVLC) comprises two loops covalently anchored to a 2,4,6-trimethyl-mesitylene core and upon binding induces disassembly of the trimeric TNFα cytokine into dimers and monomers. A 2.9 Å crystal structure of the M21/hTNFα complex reveals the peptide bound to a hTNFα dimer at a normally buried epitope in the trimer interface overlapping the binding site of a previously discovered small molecule ligand (SPD304), which also induces TNF trimer dissociation and synergizes with M21 in the inhibition of TNFα cytotoxicity. The discovery of M21 underlines the potential of semi-synthetic bicyclic peptides as ligands for the discovery of cryptic epitopes, some of which are poorly accessible to antibodies.

Mutants of Micromonospora viridifaciens sialidase have highly variable activities on natural and non-natural substrates
3:56 pm January 22, 2015

This study aimed to improve the hydrolase activity of the well-characterised bacterial sialidase from Micromonospora viridifaciens. The enzyme and its mutated versions were produced in Bacillus subtilis and secreted to the growth medium. Twenty amino acid positions in or near the active site were subjected to site-saturation mutagenesis and evaluated on the artificial sialidase substrate 2-O-(p-nitrophenyl)-α-d-N-acetylneuraminic acid and on the natural substrate casein glycomacropeptide. A considerably higher fraction of the mutants exhibited increased activity on the artificial substrate compared with the natural one, with the most proficient mutant showing a 13-fold improvement in kcat/Km. In contrast, no mutants displayed more than a 2-fold increase in activity on the natural substrate. To gain further insight into this important discrepancy, we analysed the stability of mutants using the PoPMuSiC software, a property that also correlates with the potential for introducing chemical variation, after validating the method with a set of experimental stability estimates. We found a significant correlation between improved hydrolase activity on the artificial substrate and reduced apparent stability. Together with the minor improvement on the natural substrate this shows an important difference between naturally evolved functionality and new laboratory functionality. Our results suggest that when engineering sialidases and potentially other proteins towards non-natural substrates that are not optimized by natural evolution, major changes in chemical properties are advantageous, and these changes tend to correlate with decreased stability, partly explaining commonly observed trade-offs between stability and proficiency.

Alteration of substrate specificity of alanine dehydrogenase
3:56 pm January 22, 2015

The l-alanine dehydrogenase (AlaDH) has a natural history that suggests it would not be a promising candidate for expansion of substrate specificity by protein engineering: it is the only amino acid dehydrogenase in its fold family, it has no sequence or structural similarity to any known amino acid dehydrogenase, and it has a strong preference for l-alanine over all other substrates. By contrast, engineering of the amino acid dehydrogenase superfamily members has produced catalysts with expanded substrate specificity; yet, this enzyme family already contains members that accept a broad range of substrates. To test whether the natural history of an enzyme is a predictor of its innate evolvability, directed evolution was carried out on AlaDH. A single mutation identified through molecular modeling, F94S, introduced into the AlaDH from Mycobacterium tuberculosis (MtAlaDH) completely alters its substrate specificity pattern, enabling activity toward a range of larger amino acids. Saturation mutagenesis libraries in this mutant background additionally identified a double mutant (F94S/Y117L) showing improved activity toward hydrophobic amino acids. The catalytic efficiencies achieved in AlaDH are comparable with those that resulted from similar efforts in the amino acid dehydrogenase superfamily and demonstrate the evolvability of MtAlaDH specificity toward other amino acid substrates.

Unexpected turn in diabetes research
12:00 am January 22, 2015

Unexpected turn in diabetes research<br>Years of diabetes research carried out on mice whose DNA had been altered with a human growth hormone gene is now ripe for reinterpretation after a new study shows that the gene had an unintended effect on the mice’s insulin production.

2MXT
3:59 pm January 21, 2015

NMR structure of the acidic domain of SYNCRIP (hnRNPQ)

2MJL
3:59 pm January 21, 2015

Solution structure of peptidyl-tRNA hyrolase from Vibrio cholerae

Community Skype Meeting Tonight!!!
3:30 pm January 21, 2015

Whats up everyone. We will be holding a meeting on community tools and resources and how to improve them tonight(wednesday) @ 9p EST. Anyone that would like to show up PLEASE DO. The more people we have the better.

If you don’t show up you are dead to me. :P 
See you tonight!
This week’s new structures (Tuesday Jan 20, 2015 at 4 PM PST)
12:00 am January 21, 2015

As of Tuesday Jan 20, 2015 at 4 PM PST there are 105906 Structures.
New Structure ID List:
[2MJL, 2MXT, 3J92, 3WIH, 3WII, 3WPN, 3WPQ, 3WPS, 3WPT, 3WRN, 3WRO, 3WRQ, 3WRR, 3WRS, 3WTD, 3WTF, 3WXO, 3X00, 3X17, 3X1N, 3X29, 3X2R, 4C5A, 4C5B, 4C5C, 4CBG, 4CBH, 4CBI, 4CBL, 4CBM, 4CKQ, 4CL6, 4CL8, 4CLD, 4CLE, 4CLH, 4CLO, 4CLR, 4CLX, 4CM1, 4CM3, 4CM4, 4CM5, 4CM6, 4CM7, 4CM8, 4CM9, 4CMA, 4CMB, 4CMC, 4CME, 4CMG, 4CMI, 4CMJ, 4CMK, 4CT9, 4D5E, 4D5G, 4D5R, 4D5S, 4D5T, 4D71, 4D72, 4N56, 4N5S, 4NL6, 4NL7, 4NNL, 4NNM, 4NOT, 4NR1, 4NV7, 4NV8, 4O0Q, 4O1E, 4O1F, 4O1U, 4O1X, 4OFF, 4OFG, 4OGB, 4OGU, 4OHN, 4OIC, 4OXW, 4OZ4, 4P5K, 4PJ3, 4PP4, 4PRY, 4PRZ, 4PS0, 4PS1, 4PV6, 4QAU, 4QD4, 4QSA, 4QSB, 4QSI, 4QSJ, 4R3B, 4R7G, 4R94, 4R9R, 4R9S, 4RCD, 4REL, 4REM, 4REN, 4RGM, 4RGN, 4RGO, 4RI6, 4RI7, 4RKG, 4RKH, 4RLO, 4RLP, 4RPA, 4RPG, 4RPH, 4RPJ, 4RPK, 4RPL, 4RR2, 4RVN, 4RWV, 4RXW, 4RXX, 4RZ0, 4RZM, 4S0Y, 4S12, 4TZI, 4U7D, 4U8E, 4U9E, 4U9H, 4U9I, 4UUQ, 4UXA, 4V0B, 4W5A, 4WB5, 4WB6, 4WB7, 4WB8, 4WET, 4WEY, 4WF4, 4WF5, 4WG0, 4WHM, 4WK8, 4WSG, 4WT8, 4WUS, 4WWE, 4WWT, 4X0G, 4X1E, 4X33, 4X3E, 4X3F, 4X5M, 4X5N, 4X8F, 4XCK, 4XCZ, 4XD0, 4XD1, 4XDI, 4XEU, 4XI1, 4XIU, 4XK2, 4XL8]

A chemical modified version of the second messenger cAMP
12:00 am January 21, 2015

A chemical modified version of the second messenger cAMP <br>Second messengers are small molecules that transmit signals in the cell. A single second messenger typically interacts with several signalling proteins.

несанкционированный доступ к базе данных. (Заново за 30 секунд ...) OAUTH_E354